Guides / Trans-resveratrol
Trans-resveratrol from Japanese knotweed: what you get for the price
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Resveratrol is a plant compound found in grapes, berries and peanuts, and in the root of Japanese knotweed, which is where most supplement resveratrol comes from. The product we looked at, SelfPlus AGE+, is a single-active capsule: 125 mg of trans-resveratrol, once a day. Here's what that means, what it costs, and who should ask a doctor first.
The short version
- What's inside: 250 mg Japanese knotweed root extract standardized to 50%, so 125 mg trans-resveratrol per capsule (label).
- How to take it: one capsule a day; one bottle is a 30-day supply.
- Price: $79 for 1 bottle, $177 for 3, $324 for 6. Shipping $9.99 on 1 and 3 bottles, free on 6. US addresses only.
- Guarantee: 60 days. Per the seller's refund policy, you request it through Digistore24 support, mail the product back at your own cost, and the original shipping fee is generally not refunded.
- Don't use if: you're pregnant, nursing or under 18 (the seller's label advises against it).
- Ask a doctor first if: you take blood thinners or antiplatelet drugs, take medicines processed by liver CYP enzymes, or have a hormone-sensitive condition.
Paid link. If you buy, we earn a commission from the seller; it adds nothing to your price. Prices as shown on the seller's page on November 12, 2026; check the total at checkout.
What resveratrol is
Resveratrol is a polyphenol, one of the compounds plants make to protect themselves. Its "trans" form is the one most often studied. Food sources include grape skins, red wine, peanuts, pistachios, blueberries and cranberries, but the amounts are small, so supplements usually extract it from Japanese knotweed (Polygonum cuspidatum).
What the research says, honestly
Resveratrol has been studied for a long time, but the human evidence is mixed. Memorial Sloan Kettering's integrative-medicine database summarizes it this way: human studies are often small or limited; a meta-analysis found no benefit on cardiovascular risk factors; trials in older adults did not show a cognitive benefit; and a Cochrane review found insufficient evidence for use in diabetes. So we do not describe it as protecting the heart, the brain or blood sugar. The seller's own claim is modest: "supports healthy aging." That's a general wellness statement, not a medical one.
Who buys it, then? Mostly adults who want a plain, single-active antioxidant supplement as part of a daily routine, and who prefer a clearly stated dose over a multi-ingredient blend.
What one capsule contains
| Item | Per capsule | Note |
|---|---|---|
| Japanese knotweed root extract | 250 mg | Standardized to 50%, so 125 mg trans-resveratrol (label) |
| Also on the label | — | Lemongrass powder, white rice flour, magnesium stearate; cellulose capsule |
| Serving | 1 capsule a day | 30 capsules per bottle |
The 125 mg dose is moderate. Side effects such as nausea, gas, stomach pain and diarrhea have been reported mainly at much higher doses (grams per day) in studies.
What it costs
Prices on the seller's page on November 12, 2026:
| Pack | Supply | Total | Shipping | Per bottle |
|---|---|---|---|---|
| 1 bottle | 30 days | $79 | $9.99 | $79 |
| 3 bottles | 90 days | $177 | $9.99 | $59 |
| 6 bottles | 180 days | $324 | Free | $54 |
Plain resveratrol is widely sold, and some store brands cost less per bottle. What this product offers is a single, clearly labeled active ingredient at one capsule a day, US shipping in 3 to 5 days (seller's estimate), and a 60-day guarantee (return shipping at your cost; original shipping generally not refunded). Compare the dose per capsule and the source (knotweed, standardized trans-resveratrol) before comparing prices. Check your total at checkout; the seller's checkout may show its own comparison prices, which we don't repeat here.
Check the current price on the seller's page →Paid link. If you buy, we earn a commission from the seller; it adds nothing to your price. Prices as shown on the seller's page on November 12, 2026; check the total at checkout.
Who should ask a doctor first
- Blood thinners or antiplatelet drugs (for example warfarin): resveratrol inhibits platelet aggregation in lab studies, so combining them may raise bleeding risk.
- Medicines processed by liver enzymes (CYP3A4, 2D6, 2C9, 1A2): resveratrol can change how some drugs are broken down.
- Hormone-sensitive conditions: resveratrol has estrogen-like activity.
- Pregnancy, breastfeeding, under 18: don't use it; the seller's label advises against use while pregnant or nursing, and it is not intended for anyone under 18.
- Upcoming surgery: tell your surgeon about every supplement you take.
Who it may suit
Healthy adults who want a simple, once-daily, single-active resveratrol and are comfortable with a premium price for a clearly stated 125 mg dose. If you take any regular medication, check with your pharmacist first.
See the capsules →Paid link. If you buy, we earn a commission from the seller; it adds nothing to your price. Prices as shown on the seller's page on November 12, 2026; check the total at checkout.
Quick answers
How much resveratrol is in one capsule?
125 mg of trans-resveratrol, from 250 mg of Japanese knotweed root extract standardized to 50% (label).
Where does it come from?
Japanese knotweed root, the usual source for resveratrol supplements.
Does it prevent heart disease, diabetes or memory loss?
No. Human research has not shown that, and no supplement on this page treats or prevents any disease.
Is it a subscription?
The seller presents one-time packs of 1, 3 or 6 bottles. Check the total and the terms at checkout.
What is the guarantee?
60 days from purchase. Per the seller's refund policy, contact Digistore24 Customer Support, then return the product using their instructions. Return postage is on you, and the original $9.99 shipping is generally not refunded.
Sources
- Memorial Sloan Kettering Cancer Center: About Herbs, Resveratrol
- NIH Office of Dietary Supplements: Dietary Supplements, What You Need to Know (general background)
- Seller's page (prices, dose, policies), read November 12, 2026
These statements have not been evaluated by the Food and Drug Administration. The products discussed are not intended to diagnose, treat, cure, or prevent any disease. This page is general information, not medical advice.
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